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AK3

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GENERAL INFORMATION

Gene name

 AK3

Gene description

 Adenylate kinase 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA063324
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA063324 Hep G2 Mitochondria
HPA063324 SiHa Mitochondria
HPA063324 U-2 OS No staining    

GENE INFORMATION

Gene name

 AK3 (HGNC Symbol)

Synonyms

 AK3L1, AK6, AKL3L1

Description

 Adenylate kinase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 9

Cytoband

 p24.1

Chromosome location (bp)

 4709559 - 4742043

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147853 (version 83.38)

Entrez gene

 50808

UniProt

 Q9UIJ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIJ7

Antibodypedia

 AK3 antibodies

PROTEIN BROWSER
AK3-001
AK3-002
AK3-003
AK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK3-001
ENSP00000352948
ENST00000359883
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 157 aa
18.2 kDa 		No 0
AK3-002
ENSP00000371230
ENST00000381809
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 227 aa
25.6 kDa 		No 0
AK3-003
ENSP00000413933
ENST00000447596
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 187 aa
21 kDa 		No 0
AK3-201
ENSP00000482308
ENST00000611749
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 157 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.