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AK3

GENERAL INFORMATION

Gene name

 AK3

Gene description

 Adenylate kinase 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA063324
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA063324

GENE INFORMATION

Gene name

 AK3 (HGNC Symbol)

Synonyms

 AK3L1, AK6, AKL3L1

Description

 Adenylate kinase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 9

Cytoband

 p24.1

Chromosome location (bp)

 4709559 - 4742043

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147853 (version 83.38)

Entrez gene

 50808

UniProt

 Q9UIJ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIJ7

Antibodypedia

 AK3 antibodies

PROTEIN BROWSER
AK3-001
AK3-002
AK3-003
AK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK3-001
ENSP00000352948
ENST00000359883
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 157 aa
18.2 kDa 		No 0
AK3-002
ENSP00000371230
ENST00000381809
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 227 aa
25.6 kDa 		No 0
AK3-003
ENSP00000413933
ENST00000447596
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 187 aa
21 kDa 		No 0
AK3-201
ENSP00000482308
ENST00000611749
Q9UIJ7 [Direct mapping]
GTP:AMP phosphotransferase AK3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006172 [ADP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046041 [ITP metabolic process]
GO:0046051 [UTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
Show all
 157 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.