Cell atlas - PLIN2 - The Human Protein Atlas

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PLIN2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Lipid droplets

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PLIN2
Gene description	Perilipin 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the lipid droplets.
RNA cell category	Cell line enhanced (BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Lipid droplets (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA016607
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the lipid droplets.

Main location

Lipid droplets (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016607	Hep G2	Lipid droplets
	HPA016607	RT4	Lipid droplets
	HPA016607	U-2 OS	Lipid droplets

GENE INFORMATION
Gene name	PLIN2 (HGNC Symbol)
Synonyms	ADFP, ADRP
Description	Perilipin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Chromosome	9
Cytoband	p22.1
Chromosome location (bp)	19108375 - 19149290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147872 (version 83.38)
Entrez gene	123
UniProt	Q99541 (UniProt - Evidence at protein level)
neXtProt	NX_Q99541
Antibodypedia	PLIN2 antibodies

PROTEIN BROWSER

PLIN2-002	PLIN2-003	PLIN2-005	PLIN2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLIN2-002 ENSP00000369832 ENST00000380465	Q5SYF4 [Direct mapping] Perilipin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.7 kDa	No	0
PLIN2-003 ENSP00000369831 ENST00000380464	Q5SYF3 [Direct mapping] Perilipin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.9 kDa	No	0
PLIN2-005 ENSP00000403421 ENST00000434144	Q5SYF5 [Direct mapping] Perilipin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.2 kDa	No	0
PLIN2-007 ENSP00000276914 ENST00000276914	Q99541 [Direct mapping] Perilipin-2 Q6FHZ7 [Target identity:100%; Query identity:100%] Perilipin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0014070 [response to organic cyclic compound] GO:0015909 [long-chain fatty acid transport] GO:0019915 [lipid storage] GO:0042493 [response to drug] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	437 aa 48.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.