Expression of PLIN2 in cancer - Summary

GENERAL INFORMATION
Gene name	PLIN2
Gene description	Perilipin 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, renal cancer)
HPA (cell line):	Cell line enhanced (BEWO)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues. Additional plasma positivity in a few tissues including lactating breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA016607 , CAB037331
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA016607	CAB037331

GENE INFORMATION
Gene name	PLIN2 (HGNC Symbol)
Synonyms	ADFP, ADRP
Description	Perilipin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Chromosome	9
Cytoband	p22.1
Chromosome location (bp)	19108375 - 19149290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147872 (version 83.38)
Entrez gene	123
UniProt	Q99541 (UniProt - Evidence at protein level)
neXtProt	NX_Q99541
Antibodypedia	PLIN2 antibodies

PROTEIN BROWSER

PLIN2-002	PLIN2-003	PLIN2-005	PLIN2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLIN2-002 ENSP00000369832 ENST00000380465	Q5SYF4 [Direct mapping] Perilipin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.7 kDa	No	0
PLIN2-003 ENSP00000369831 ENST00000380464	Q5SYF3 [Direct mapping] Perilipin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.9 kDa	No	0
PLIN2-005 ENSP00000403421 ENST00000434144	Q5SYF5 [Direct mapping] Perilipin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.2 kDa	No	0
PLIN2-007 ENSP00000276914 ENST00000276914	Q99541 [Direct mapping] Perilipin-2 Q6FHZ7 [Target identity:100%; Query identity:100%] Perilipin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0014070 [response to organic cyclic compound] GO:0015909 [long-chain fatty acid transport] GO:0019915 [lipid storage] GO:0042493 [response to drug] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	437 aa 48.1 kDa	No	0