Cell atlas - HAUS6 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HAUS6
Gene description	HAUS augmin-like complex, subunit 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & microtubule organizing center. In addition localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (supported), Cytosol (supported)
Additional location	In addition localized to the Nuclear speckles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA020965
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & microtubule organizing center. In addition localized to the nuclear speckles.

Main location

Microtubule organizing center (supported), Cytosol (supported)

Additional location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA020965	A-431	Nuclear speckles
		Microtubule organizing center
		Cytosol	Intensity
HPA020965	U-2 OS	Nuclear speckles
HPA020965	U-2 OS	Cytosol	Intensity
HPA020965	U-251 MG	Microtubule organizing center
HPA020965	U-251 MG	Cytosol	Intensity

GENE INFORMATION
Gene name	HAUS6 (HGNC Symbol)
Synonyms	dgt6, FAM29A, FLJ20060, KIAA1574
Description	HAUS augmin-like complex, subunit 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Chromosome	9
Cytoband	p22.1
Chromosome location (bp)	19053143 - 19103119
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147874 (version 83.38)
Entrez gene	54801
UniProt	Q7Z4H7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4H7
Antibodypedia	HAUS6 antibodies

PROTEIN BROWSER

HAUS6-001	HAUS6-002	HAUS6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAUS6-001 ENSP00000369871 ENST00000380502	Q7Z4H7 [Direct mapping] HAUS augmin-like complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0007067 [mitotic nuclear division] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	955 aa 108.6 kDa	No	0
HAUS6-002 ENSP00000369865 ENST00000380496	Q5VY60 [Direct mapping] HAUS augmin-like complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0070652 [HAUS complex] Show all	802 aa 91.1 kDa	No	0
HAUS6-003 ENSP00000409615 ENST00000415524	Q5SYF9 [Direct mapping] HAUS augmin-like complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0070652 [HAUS complex] Show all	183 aa 20.6 kDa	No	0