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HAUS6

GENERAL INFORMATION

Gene name

 HAUS6

Gene description

 HAUS augmin-like complex, subunit 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020960 , HPA020965
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA020960
HPA020965

GENE INFORMATION

Gene name

 HAUS6 (HGNC Symbol)

Synonyms

 dgt6, FAM29A, FLJ20060, KIAA1574

Description

 HAUS augmin-like complex, subunit 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Chromosome

 9

Cytoband

 p22.1

Chromosome location (bp)

 19053143 - 19103119

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147874 (version 83.38)

Entrez gene

 54801

UniProt

 Q7Z4H7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z4H7

Antibodypedia

 HAUS6 antibodies

PROTEIN BROWSER
HAUS6-001
HAUS6-002
HAUS6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAUS6-001
ENSP00000369871
ENST00000380502
Q7Z4H7 [Direct mapping]
HAUS augmin-like complex subunit 6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0007067 [mitotic nuclear division]
GO:0051225 [spindle assembly]
GO:0051297 [centrosome organization]
GO:0051301 [cell division]
GO:0070652 [HAUS complex]
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 955 aa
108.6 kDa 		No 0
HAUS6-002
ENSP00000369865
ENST00000380496
Q5VY60 [Direct mapping]
HAUS augmin-like complex subunit 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0051225 [spindle assembly]
GO:0051297 [centrosome organization]
GO:0070652 [HAUS complex]
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 802 aa
91.1 kDa 		No 0
HAUS6-003
ENSP00000409615
ENST00000415524
Q5SYF9 [Direct mapping]
HAUS augmin-like complex subunit 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0051225 [spindle assembly]
GO:0051297 [centrosome organization]
GO:0070652 [HAUS complex]
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 183 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.