Expression of SIGMAR1 in cancer - Summary - The Human Protein Atlas

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SIGMAR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SIGMAR1
Gene description	Sigma non-opioid intracellular receptor 1
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA018002 , HPA024071 , CAB013470
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018002	HPA024071	CAB013470

GENE INFORMATION
Gene name	SIGMAR1 (HGNC Symbol)
Synonyms	OPRS1, SR-BP1
Description	Sigma non-opioid intracellular receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	34634722 - 34637809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147955 (version 83.38)
Entrez gene	10280
UniProt	Q99720 (UniProt - Evidence at protein level)
neXtProt	NX_Q99720
Antibodypedia	SIGMAR1 antibodies

PROTEIN BROWSER

SIGMAR1-001	SIGMAR1-002	SIGMAR1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIGMAR1-001 ENSP00000277010 ENST00000277010	Q99720 [Direct mapping] Sigma non-opioid intracellular receptor 1 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004985 [opioid receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005640 [nuclear outer membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0005887 [integral component of plasma membrane] GO:0006869 [lipid transport] GO:0007399 [nervous system development] GO:0008144 [drug binding] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030426 [growth cone] GO:0038003 [opioid receptor signaling pathway] GO:0043523 [regulation of neuron apoptotic process] Show all	223 aa 25.1 kDa	No	1
SIGMAR1-002 ENSP00000368170 ENST00000378892	Q5T1J1 [Direct mapping] HCG20471, isoform CRA_c; Sigma non-opioid intracellular receptor 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0006869 [lipid transport] Show all	134 aa 14.9 kDa	Yes	0
SIGMAR1-008 ENSP00000420022 ENST00000477726	Q99720 [Direct mapping] Sigma non-opioid intracellular receptor 1 A2A3U5 [Target identity:100%; Query identity:100%] HCG20471, isoform CRA_d; cDNA FLJ76396, highly similar to Homo sapiens opioid receptor, sigma 1 (OPRS1), transcript variant 2, mRNA Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005640 [nuclear outer membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0005887 [integral component of plasma membrane] GO:0006869 [lipid transport] GO:0008144 [drug binding] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030426 [growth cone] GO:0043523 [regulation of neuron apoptotic process] Show all	192 aa 21.5 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.