Cell atlas - C9orf3 - The Human Protein Atlas

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C9orf3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	C9orf3
Gene description	Chromosome 9 open reading frame 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA072729
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions.

Main location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072729	A549	Cell Junctions
	HPA072729	HaCaT	No staining
	HPA072729	U-2 OS	Cell Junctions

GENE INFORMATION
Gene name	C9orf3 (HGNC Symbol)
Synonyms	AOPEP, AP-O, APO, C90RF3, FLJ14675
Description	Chromosome 9 open reading frame 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Chromosome	9
Cytoband	q22.32
Chromosome location (bp)	94726701 - 95087218
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148120 (version 83.38)
Entrez gene	84909
UniProt	Q8N6M6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6M6
Antibodypedia	C9orf3 antibodies

PROTEIN BROWSER

C9orf3-002	C9orf3-003	C9orf3-004	C9orf3-006	C9orf3-008	C9orf3-015	C9orf3-018	C9orf3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C9orf3-002 ENSP00000297979 ENST00000297979	Q8N6M6 [Direct mapping] Aminopeptidase O Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0004177 [aminopeptidase activity] GO:0004301 [epoxide hydrolase activity] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	720 aa 82.1 kDa	No	0
C9orf3-003 ENSP00000387736 ENST00000427193	X6RBX4 [Direct mapping] Aminopeptidase O Show all	Predicted intracellular proteins Show all	GO:0006508 [proteolysis] Show all	140 aa 15.9 kDa	No	0
C9orf3-004 ENSP00000277198 ENST00000277198	Q8N6M6 [Direct mapping] Aminopeptidase O Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Show all	GO:0004177 [aminopeptidase activity] GO:0004301 [epoxide hydrolase activity] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	566 aa 63.4 kDa	No	0
C9orf3-006 ENSP00000402171 ENST00000424143	A0A0A0MSU0 [Direct mapping] Aminopeptidase O Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] Show all	508 aa 58.3 kDa	No	0
C9orf3-008 ENSP00000401854 ENST00000428313	A0A0A0MST7 [Direct mapping] Aminopeptidase O Show all	Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] Show all	601 aa 69.2 kDa	No	0
C9orf3-015 ENSP00000413927 ENST00000445181	H0Y7M4 [Direct mapping] Aminopeptidase O Show all	Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] Show all	184 aa 21.1 kDa	No	0
C9orf3-018 ENSP00000411451 ENST00000451893	H0Y7A8 [Direct mapping] Aminopeptidase O Show all	Predicted intracellular proteins Show all	GO:0006508 [proteolysis] Show all	145 aa 17.5 kDa	No	0
C9orf3-201 ENSP00000364464 ENST00000375315	Q8N6M6 [Direct mapping] Aminopeptidase O Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Show all	GO:0004177 [aminopeptidase activity] GO:0004301 [epoxide hydrolase activity] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	819 aa 93.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.