Fields »
ABOUT
HELP
BLOG
C9orf3

GENERAL INFORMATION

Gene name

 C9orf3

Gene description

 Chromosome 9 open reading frame 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004633
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004633

GENE INFORMATION

Gene name

 C9orf3 (HGNC Symbol)

Synonyms

 AOPEP, AP-O, APO, C90RF3, FLJ14675

Description

 Chromosome 9 open reading frame 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Chromosome

 9

Cytoband

 q22.32

Chromosome location (bp)

 94726701 - 95087218

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148120 (version 83.38)

Entrez gene

 84909

UniProt

 Q8N6M6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N6M6

Antibodypedia

 C9orf3 antibodies

PROTEIN BROWSER
C9orf3-002
C9orf3-003
C9orf3-004
C9orf3-006
C9orf3-008
C9orf3-015
C9orf3-018
C9orf3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C9orf3-002
ENSP00000297979
ENST00000297979
Q8N6M6 [Direct mapping]
Aminopeptidase O
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0005488 [binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0070006 [metalloaminopeptidase activity]
Show all
 720 aa
82.1 kDa 		No 0
C9orf3-003
ENSP00000387736
ENST00000427193
X6RBX4 [Direct mapping]
Aminopeptidase O
Show all
Predicted intracellular proteins
Show all
GO:0006508 [proteolysis]
Show all
 140 aa
15.9 kDa 		No 0
C9orf3-004
ENSP00000277198
ENST00000277198
Q8N6M6 [Direct mapping]
Aminopeptidase O
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Show all
GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0070006 [metalloaminopeptidase activity]
Show all
 566 aa
63.4 kDa 		No 0
C9orf3-006
ENSP00000402171
ENST00000424143
A0A0A0MSU0 [Direct mapping]
Aminopeptidase O
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005488 [binding]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
Show all
 508 aa
58.3 kDa 		No 0
C9orf3-008
ENSP00000401854
ENST00000428313
A0A0A0MST7 [Direct mapping]
Aminopeptidase O
Show all
Predicted intracellular proteins
Show all
GO:0005488 [binding]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
Show all
 601 aa
69.2 kDa 		No 0
C9orf3-015
ENSP00000413927
ENST00000445181
H0Y7M4 [Direct mapping]
Aminopeptidase O
Show all
Predicted intracellular proteins
Show all
GO:0005488 [binding]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
Show all
 184 aa
21.1 kDa 		No 0
C9orf3-018
ENSP00000411451
ENST00000451893
H0Y7A8 [Direct mapping]
Aminopeptidase O
Show all
Predicted intracellular proteins
Show all
GO:0006508 [proteolysis]
Show all
 145 aa
17.5 kDa 		No 0
C9orf3-201
ENSP00000364464
ENST00000375315
Q8N6M6 [Direct mapping]
Aminopeptidase O
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Show all
GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0005488 [binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0070006 [metalloaminopeptidase activity]
Show all
 819 aa
93.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.