Cell atlas - ASTN2 - The Human Protein Atlas

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ASTN2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ASTN2
Gene description	Astrotactin 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA027035
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

Cytosol (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027035	A-431	Nucleoplasm
	HPA027035	A-431	Cytosol	Intensity
	HPA027035	U-2 OS	Nucleoplasm
	HPA027035	U-2 OS	Cytosol	Intensity

GENE INFORMATION
Gene name	ASTN2 (HGNC Symbol)
Synonyms	KIAA0634
Description	Astrotactin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
Chromosome	9
Cytoband	q33.1
Chromosome location (bp)	116425225 - 117415070
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148219 (version 83.38)
Entrez gene	23245
UniProt	O75129 (UniProt - Evidence at transcript level)
neXtProt	NX_O75129
Antibodypedia	ASTN2 antibodies

PROTEIN BROWSER

ASTN2-001	ASTN2-002	ASTN2-003	ASTN2-004	ASTN2-005	ASTN2-006	ASTN2-201	ASTN2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASTN2-001 ENSP00000354504 ENST00000361209	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005768 [endosome] GO:0016021 [integral component of membrane] GO:0060187 [cell pole] GO:2000009 [negative regulation of protein localization to cell surface] Show all	1288 aa 142.5 kDa	Yes	2
ASTN2-002 ENSP00000288520 ENST00000288520	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	440 aa 49.6 kDa	No	0
ASTN2-003 ENSP00000412099 ENST00000417725	H7C3I6 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Show all		98 aa 11.1 kDa	No	0
ASTN2-004 ENSP00000351460 ENST00000358637	X6R5P2 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		194 aa 21.7 kDa	No	0
ASTN2-005 ENSP00000363098 ENST00000373986	H0Y3A8 [Direct mapping] Astrotactin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005768 [endosome] Show all	1062 aa 118.8 kDa	No	1
ASTN2-006 ENSP00000339925 ENST00000341734	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	395 aa 44.6 kDa	No	0
ASTN2-201 ENSP00000314038 ENST00000313400	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] Show all	1339 aa 148.2 kDa	Yes	2
ASTN2-202 ENSP00000355116 ENST00000361477	B7ZKP5 [Direct mapping] ASTN2 protein; Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	402 aa 45.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.