Tissue expression of ASTN2 - Summary - The Human Protein Atlas

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ASTN2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ASTN2
Gene description	Astrotactin 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA027035
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	ASTN2 (HGNC Symbol)
Synonyms	KIAA0634
Description	Astrotactin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
Chromosome	9
Cytoband	q33.1
Chromosome location (bp)	116425225 - 117415070
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148219 (version 83.38)
Entrez gene	23245
UniProt	O75129 (UniProt - Evidence at transcript level)
neXtProt	NX_O75129
Antibodypedia	ASTN2 antibodies

PROTEIN BROWSER

ASTN2-001	ASTN2-002	ASTN2-003	ASTN2-004	ASTN2-005	ASTN2-006	ASTN2-201	ASTN2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASTN2-001 ENSP00000354504 ENST00000361209	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005768 [endosome] GO:0016021 [integral component of membrane] GO:0060187 [cell pole] GO:2000009 [negative regulation of protein localization to cell surface] Show all	1288 aa 142.5 kDa	Yes	2
ASTN2-002 ENSP00000288520 ENST00000288520	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	440 aa 49.6 kDa	No	0
ASTN2-003 ENSP00000412099 ENST00000417725	H7C3I6 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Show all		98 aa 11.1 kDa	No	0
ASTN2-004 ENSP00000351460 ENST00000358637	X6R5P2 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		194 aa 21.7 kDa	No	0
ASTN2-005 ENSP00000363098 ENST00000373986	H0Y3A8 [Direct mapping] Astrotactin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005768 [endosome] Show all	1062 aa 118.8 kDa	No	1
ASTN2-006 ENSP00000339925 ENST00000341734	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	395 aa 44.6 kDa	No	0
ASTN2-201 ENSP00000314038 ENST00000313400	O75129 [Direct mapping] Astrotactin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] Show all	1339 aa 148.2 kDa	Yes	2
ASTN2-202 ENSP00000355116 ENST00000361477	B7ZKP5 [Direct mapping] ASTN2 protein; Astrotactin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	402 aa 45.3 kDa	No	0

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The Human Protein Atlas

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by the Knut & Alice Wallenberg foundation.