Cell atlas - MED22 - The Human Protein Atlas

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MED22

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MED22
Gene description	Mediator complex subunit 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063694
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063694	CACO-2	Nucleoplasm
	HPA063694	HeLa	Nucleoplasm
	HPA063694	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	MED22 (HGNC Symbol)
Synonyms	Med24, SURF5
Description	Mediator complex subunit 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	133338323 - 133348131
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148297 (version 83.38)
Entrez gene	6837
UniProt	Q15528 (UniProt - Evidence at protein level)
neXtProt	NX_Q15528
Antibodypedia	MED22 antibodies

PROTEIN BROWSER

MED22-002	MED22-003	MED22-005	MED22-006	MED22-007	MED22-008	MED22-010	MED22-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED22-002 ENSP00000342343 ENST00000343730	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 A0A024R8C5 [Target identity:100%; Query identity:100%] Surfeit 5, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	200 aa 22.2 kDa	No	0
MED22-003 ENSP00000361067 ENST00000371999	Q5T8T7 [Direct mapping] Mediator complex subunit 22; Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	134 aa 15.9 kDa	No	0
MED22-005 ENSP00000394781 ENST00000446777	Q5T8T8 [Direct mapping] Mediator complex subunit 22; Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	137 aa 16 kDa	No	0
MED22-006 ENSP00000478773 ENST00000610888	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	140 aa 16.5 kDa	No	0
MED22-007 ENSP00000482438 ENST00000610672	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 A0A024R8C5 [Target identity:100%; Query identity:100%] Surfeit 5, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	200 aa 22.2 kDa	No	0
MED22-008 ENSP00000481493 ENST00000614493	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	140 aa 16.5 kDa	No	0
MED22-010 ENSP00000404178 ENST00000457204	E9PGW7 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	111 aa 12.9 kDa	No	0
MED22-011 ENSP00000420815 ENST00000494177	E7EN96 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	135 aa 15.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.