Expression of MED22 in cancer - Summary - The Human Protein Atlas

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MED22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MED22
Gene description	Mediator complex subunit 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA020391
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020391

GENE INFORMATION
Gene name	MED22 (HGNC Symbol)
Synonyms	Med24, SURF5
Description	Mediator complex subunit 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	133338323 - 133348131
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148297 (version 83.38)
Entrez gene	6837
UniProt	Q15528 (UniProt - Evidence at protein level)
neXtProt	NX_Q15528
Antibodypedia	MED22 antibodies

PROTEIN BROWSER

MED22-002	MED22-003	MED22-005	MED22-006	MED22-007	MED22-008	MED22-010	MED22-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED22-002 ENSP00000342343 ENST00000343730	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 A0A024R8C5 [Target identity:100%; Query identity:100%] Surfeit 5, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	200 aa 22.2 kDa	No	0
MED22-003 ENSP00000361067 ENST00000371999	Q5T8T7 [Direct mapping] Mediator complex subunit 22; Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	134 aa 15.9 kDa	No	0
MED22-005 ENSP00000394781 ENST00000446777	Q5T8T8 [Direct mapping] Mediator complex subunit 22; Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	137 aa 16 kDa	No	0
MED22-006 ENSP00000478773 ENST00000610888	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	140 aa 16.5 kDa	No	0
MED22-007 ENSP00000482438 ENST00000610672	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 A0A024R8C5 [Target identity:100%; Query identity:100%] Surfeit 5, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	200 aa 22.2 kDa	No	0
MED22-008 ENSP00000481493 ENST00000614493	Q15528 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	140 aa 16.5 kDa	No	0
MED22-010 ENSP00000404178 ENST00000457204	E9PGW7 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	111 aa 12.9 kDa	No	0
MED22-011 ENSP00000420815 ENST00000494177	E7EN96 [Direct mapping] Mediator of RNA polymerase II transcription subunit 22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	135 aa 15.9 kDa	No	0

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The Human Protein Atlas

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