Expression of SH3GLB2 in cancer - Summary - The Human Protein Atlas

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SH3GLB2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SH3GLB2
Gene description	SH3-domain GRB2-like endophilin B2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA021438 , HPA024734
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), renal cancer (favourable) and urothelial cancer (favourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA021438	HPA024734

GENE INFORMATION
Gene name	SH3GLB2 (HGNC Symbol)
Synonyms	KIAA1848
Description	SH3-domain GRB2-like endophilin B2 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129007036 - 129028303
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148341 (version 83.38)
Entrez gene	56904
UniProt	Q9NR46 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR46
Antibodypedia	SH3GLB2 antibodies

PROTEIN BROWSER

SH3GLB2-001	SH3GLB2-002	SH3GLB2-008	SH3GLB2-011	SH3GLB2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SH3GLB2-001 ENSP00000361645 ENST00000372564	Q9NR46 [Direct mapping] Endophilin-B2 A0A024R896 [Target identity:100%; Query identity:100%] SH3-domain GRB2-like endophilin B2, isoform CRA_a Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	395 aa 44 kDa	No	0
SH3GLB2-002 ENSP00000361640 ENST00000372559	Q9NR46 [Direct mapping] Endophilin-B2 A0A024R896 [Target identity:100%; Query identity:100%] SH3-domain GRB2-like endophilin B2, isoform CRA_a Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	395 aa 44 kDa	No	0
SH3GLB2-008 ENSP00000361634 ENST00000372554	Q9NR46 [Direct mapping] Endophilin-B2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	404 aa 44.8 kDa	No	0
SH3GLB2-011 ENSP00000402566 ENST00000417224	B7ZC38 [Direct mapping] Endophilin-B2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	400 aa 44.4 kDa	No	0
SH3GLB2-012 ENSP00000388282 ENST00000416629	B7ZC39 [Direct mapping] Endophilin-B2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	374 aa 41.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.