Cell atlas - DPH7 - The Human Protein Atlas

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DPH7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DPH7
Gene description	Diphthamide biosynthesis 7
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA022911
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA022911	A-431	Nuclear bodies	Intensity
	HPA022911	U-251 MG	Nuclear bodies	Intensity

GENE INFORMATION
Gene name	DPH7 (HGNC Symbol)
Synonyms	C9orf112, FLJ90634, RRT2, WDR85
Description	Diphthamide biosynthesis 7 (HGNC Symbol)
Entrez gene summary	WDR85 is a WD repeat-containing protein that plays a role in the first step of diphthamide biosynthesis (Carette et al., 2009 [PubMed 19965467]).[supplied by OMIM, Feb 2010]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137554904 - 137578935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148399 (version 83.38)
Entrez gene	92715
UniProt	Q9BTV6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTV6
Antibodypedia	DPH7 antibodies

PROTEIN BROWSER

DPH7-009	DPH7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPH7-009 ENSP00000277540 ENST00000277540	Q9BTV6 [Direct mapping] Diphthine methyltransferase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061685 [diphthine methylesterase activity] Show all	452 aa 50.6 kDa	No	0
DPH7-201 ENSP00000485026 ENST00000615714	A0A087X2J5 [Direct mapping] Diphthine methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	227 aa 25.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.