Expression of DPH7 in cancer - Summary - The Human Protein Atlas

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DPH7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPH7
Gene description	Diphthamide biosynthesis 7
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA022911
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022911

GENE INFORMATION
Gene name	DPH7 (HGNC Symbol)
Synonyms	C9orf112, FLJ90634, RRT2, WDR85
Description	Diphthamide biosynthesis 7 (HGNC Symbol)
Entrez gene summary	WDR85 is a WD repeat-containing protein that plays a role in the first step of diphthamide biosynthesis (Carette et al., 2009 [PubMed 19965467]).[supplied by OMIM, Feb 2010]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137554904 - 137578935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148399 (version 83.38)
Entrez gene	92715
UniProt	Q9BTV6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTV6
Antibodypedia	DPH7 antibodies

PROTEIN BROWSER

DPH7-009	DPH7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPH7-009 ENSP00000277540 ENST00000277540	Q9BTV6 [Direct mapping] Diphthine methyltransferase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061685 [diphthine methylesterase activity] Show all	452 aa 50.6 kDa	No	0
DPH7-201 ENSP00000485026 ENST00000615714	A0A087X2J5 [Direct mapping] Diphthine methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	227 aa 25.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.