Cell atlas - CACNA1B - The Human Protein Atlas

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CACNA1B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CACNA1B
Gene description	Calcium channel, voltage-dependent, N type, alpha 1B subunit
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CACNA1B (HGNC Symbol)
Synonyms	CACNL1A5, CACNN, Cav2.2
Description	Calcium channel, voltage-dependent, N type, alpha 1B subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137877789 - 138124624
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148408 (version 83.38)
Entrez gene	774
UniProt	Q00975 (UniProt - Evidence at protein level)
neXtProt	NX_Q00975
Antibodypedia	CACNA1B antibodies

PROTEIN BROWSER

CACNA1B-001	CACNA1B-002	CACNA1B-003	CACNA1B-004	CACNA1B-005	CACNA1B-201	CACNA1B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA1B-001 ENSP00000360423 ENST00000371372	Q00975 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007626 [locomotory behavior] GO:0008016 [regulation of heart contraction] GO:0008022 [protein C-terminus binding] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0043025 [neuronal cell body] GO:0048265 [response to pain] GO:0051899 [membrane depolarization] GO:0051924 [regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2339 aa 262.5 kDa	No	>9
CACNA1B-002 ENSP00000277551 ENST00000277551	Q00975 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0008022 [protein C-terminus binding] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0086010 [membrane depolarization during action potential] Show all	2237 aa 251.7 kDa	No	>9
CACNA1B-003 ENSP00000360414 ENST00000371363	B1AQK6 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2337 aa 262.3 kDa	No	>9
CACNA1B-004 ENSP00000413042 ENST00000413253	H0Y7I8 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	165 aa 19 kDa	Yes	1
CACNA1B-005 ENSP00000360408 ENST00000371357	B1AQK7 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2338 aa 262.3 kDa	No	>9
CACNA1B-201 ENSP00000277549 ENST00000277549	E9PDR3 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2237 aa 251.7 kDa	No	>9
CACNA1B-202 ENSP00000360406 ENST00000371355	F6RH32 [Direct mapping] Voltage-dependent N-type calcium channel subunit alpha-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2340 aa 262.6 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.