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CACNA1B

GENERAL INFORMATION

Gene name

 CACNA1B

Gene description

 Calcium channel, voltage-dependent, N type, alpha 1B subunit

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Group enriched (adrenal gland, cerebral cortex, fallopian tube, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA044347
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044347

GENE INFORMATION

Gene name

 CACNA1B (HGNC Symbol)

Synonyms

 CACNL1A5, CACNN, Cav2.2

Description

 Calcium channel, voltage-dependent, N type, alpha 1B subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137877789 - 138124624

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148408 (version 83.38)

Entrez gene

 774

UniProt

 Q00975 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00975

Antibodypedia

 CACNA1B antibodies

PROTEIN BROWSER
CACNA1B-001
CACNA1B-002
CACNA1B-003
CACNA1B-004
CACNA1B-005
CACNA1B-201
CACNA1B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNA1B-001
ENSP00000360423
ENST00000371372
Q00975 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0008022 [protein C-terminus binding]
GO:0008217 [regulation of blood pressure]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043025 [neuronal cell body]
GO:0048265 [response to pain]
GO:0051899 [membrane depolarization]
GO:0051924 [regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2339 aa
262.5 kDa 		No >9
CACNA1B-002
ENSP00000277551
ENST00000277551
Q00975 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0008022 [protein C-terminus binding]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0086010 [membrane depolarization during action potential]
Show all
 2237 aa
251.7 kDa 		No >9
CACNA1B-003
ENSP00000360414
ENST00000371363
B1AQK6 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2337 aa
262.3 kDa 		No >9
CACNA1B-004
ENSP00000413042
ENST00000413253
H0Y7I8 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 165 aa
19 kDa 		Yes 1
CACNA1B-005
ENSP00000360408
ENST00000371357
B1AQK7 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2338 aa
262.3 kDa 		No >9
CACNA1B-201
ENSP00000277549
ENST00000277549
E9PDR3 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2237 aa
251.7 kDa 		No >9
CACNA1B-202
ENSP00000360406
ENST00000371355
F6RH32 [Direct mapping]
Voltage-dependent N-type calcium channel subunit alpha-1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2340 aa
262.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.