Cell atlas - ST8SIA6 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ST8SIA6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ST8SIA6
Gene description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enriched (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA072708
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072708	MCF7	Endoplasmic reticulum
	HPA072708	SK-MEL-30	Endoplasmic reticulum
	HPA072708	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	ST8SIA6 (HGNC Symbol)
Synonyms	SIAT8F
Description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (HGNC Symbol)
Entrez gene summary	Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	p12.33
Chromosome location (bp)	17318383 - 17454330
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148488 (version 83.38)
Entrez gene	338596
UniProt	P61647 (UniProt - Evidence at transcript level)
neXtProt	NX_P61647
Antibodypedia	ST8SIA6 antibodies

PROTEIN BROWSER

ST8SIA6-001	ST8SIA6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST8SIA6-001 ENSP00000366827 ENST00000377602	P61647 [Direct mapping] Alpha-2,8-sialyltransferase 8F Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001574 [ganglioside biosynthetic process] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0008373 [sialyltransferase activity] GO:0009100 [glycoprotein metabolic process] GO:0009247 [glycolipid biosynthetic process] GO:0009311 [oligosaccharide metabolic process] GO:0016051 [carbohydrate biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	398 aa 44.8 kDa	Yes	0
ST8SIA6-002 ENSP00000388343 ENST00000440449	H0Y405 [Direct mapping] Alpha-2,8-sialyltransferase 8F Show all	Predicted intracellular proteins Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0016021 [integral component of membrane] GO:0097503 [sialylation] Show all	128 aa 14.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.