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ST8SIA6

GENERAL INFORMATION

Gene name

 ST8SIA6

Gene description

 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (breast cancer)
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enhanced (breast, lung)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA011635
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011635

GENE INFORMATION

Gene name

 ST8SIA6 (HGNC Symbol)

Synonyms

 SIAT8F

Description

 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (HGNC Symbol)

Entrez gene summary

 Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 p12.33

Chromosome location (bp)

 17318383 - 17454330

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148488 (version 83.38)

Entrez gene

 338596

UniProt

 P61647 (UniProt - Evidence at transcript level)

neXtProt

 NX_P61647

Antibodypedia

 ST8SIA6 antibodies

PROTEIN BROWSER
ST8SIA6-001
ST8SIA6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ST8SIA6-001
ENSP00000366827
ENST00000377602
P61647 [Direct mapping]
Alpha-2,8-sialyltransferase 8F
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0006486 [protein glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009247 [glycolipid biosynthetic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0016051 [carbohydrate biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030173 [integral component of Golgi membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
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 398 aa
44.8 kDa 		Yes 0
ST8SIA6-002
ENSP00000388343
ENST00000440449
H0Y405 [Direct mapping]
Alpha-2,8-sialyltransferase 8F
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Predicted intracellular proteins
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GO:0005794 [Golgi apparatus]
GO:0006486 [protein glycosylation]
GO:0008373 [sialyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0097503 [sialylation]
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 128 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.