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A1CF

GENERAL INFORMATION

Gene name

 A1CF

Gene description

 APOBEC1 complementation factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Group enriched (CACO-2, Hep G2)
HPA (normal tissue):Tissue enhanced (duodenum, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in gastrointestinal tract, liver, pancreas and kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA037779 , HPA044079
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037779
HPA044079

GENE INFORMATION

Gene name

 A1CF (HGNC Symbol)

Synonyms

 ACF, ACF64, ACF65, APOBEC1CF, ASP

Description

 APOBEC1 complementation factor (HGNC Symbol)

Entrez gene summary

 Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 10

Cytoband

 q11.23

Chromosome location (bp)

 50799409 - 50885675

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148584 (version 83.38)

Entrez gene

 29974

UniProt

 Q9NQ94 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQ94

Antibodypedia

 A1CF antibodies

PROTEIN BROWSER
A1CF-001
A1CF-002
A1CF-003
A1CF-004
A1CF-006
A1CF-201
A1CF-202
A1CF-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
A1CF-001
ENSP00000363113
ENST00000374001
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZJ5 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 586 aa
64.3 kDa 		No 0
A1CF-002
ENSP00000363105
ENST00000373993
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZM7 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
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 594 aa
65.2 kDa 		No 0
A1CF-003
ENSP00000397953
ENST00000414883
Q5T0W7 [Direct mapping]
APOBEC1 complementation factor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 201 aa
22.5 kDa 		No 0
A1CF-004
ENSP00000363109
ENST00000373997
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZJ5 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 586 aa
64.3 kDa 		No 0
A1CF-006
ENSP00000363107
ENST00000373995
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZI9 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 594 aa
65 kDa 		No 0
A1CF-201
ENSP00000282641
ENST00000282641
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZJ5 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 586 aa
64.3 kDa 		No 0
A1CF-202
ENSP00000378868
ENST00000395489
F8W9F8 [Direct mapping]
APOBEC1 complementation factor
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0010609 [mRNA localization resulting in posttranscriptional regulation of gene expression]
GO:0016556 [mRNA modification]
Show all
 602 aa
66 kDa 		No 0
A1CF-203
ENSP00000378873
ENST00000395495
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZI9 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 594 aa
65 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.