Expression of HABP2 in cancer - Summary - The Human Protein Atlas

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HABP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HABP2
Gene description	Hyaluronan binding protein 2
Protein class	Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (RPTEC TERT1)
HPA (normal tissue):	Group enriched (gallbladder, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits and cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA019518
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019518

GENE INFORMATION
Gene name	HABP2 (HGNC Symbol)
Synonyms	FSAP, HABP, HGFAL, PHBP
Description	Hyaluronan binding protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Chromosome	10
Cytoband	q25.3
Chromosome location (bp)	113550837 - 113589602
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148702 (version 83.38)
Entrez gene	3026
UniProt	Q14520 (UniProt - Evidence at protein level)
neXtProt	NX_Q14520
Antibodypedia	HABP2 antibodies

PROTEIN BROWSER

HABP2-001	HABP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HABP2-001 ENSP00000277903 ENST00000351270	Q14520 [Direct mapping] Hyaluronan-binding protein 2 Hyaluronan-binding protein 2 50 kDa heavy chain Hyaluronan-binding protein 2 50 kDa heavy chain alternate form Hyaluronan-binding protein 2 27 kDa light chain Hyaluronan-binding protein 2 27 kDa light chain alternate form Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] Show all	560 aa 62.7 kDa	Yes	0
HABP2-201 ENSP00000443283 ENST00000542051	Q14520 [Direct mapping] Hyaluronan-binding protein 2 Hyaluronan-binding protein 2 50 kDa heavy chain Hyaluronan-binding protein 2 50 kDa heavy chain alternate form Hyaluronan-binding protein 2 27 kDa light chain Hyaluronan-binding protein 2 27 kDa light chain alternate form Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] Show all	534 aa 59.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.