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Extracellular deposits and cytoplasmic expression in several different tissue types.
DATA RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Q14520 [Direct mapping] Hyaluronan-binding protein 2 Hyaluronan-binding protein 2 50 kDa heavy chain Hyaluronan-binding protein 2 50 kDa heavy chain alternate form Hyaluronan-binding protein 2 27 kDa light chain Hyaluronan-binding protein 2 27 kDa light chain alternate form
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Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q14520 [Direct mapping] Hyaluronan-binding protein 2 Hyaluronan-binding protein 2 50 kDa heavy chain Hyaluronan-binding protein 2 50 kDa heavy chain alternate form Hyaluronan-binding protein 2 27 kDa light chain Hyaluronan-binding protein 2 27 kDa light chain alternate form
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Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
