Cell atlas - MKI67 - The Human Protein Atlas

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MKI67

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MKI67
Gene description	Marker of proliferation Ki-67
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus, nucleoli & nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated), Nucleoli (validated), Nuclear bodies (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. CAB000058 , HPA000451 , HPA001164
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus, nucleoli & nuclear bodies.

Main location

Nucleus (validated), Nucleoli (validated), Nuclear bodies (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001164	A-431	Nucleus	Spatial
	HPA001164	A-431	Nucleoli	Spatial
	HPA001164	U-2 OS	Nucleoli	Spatial
	HPA001164	U-2 OS	Nuclear bodies	Spatial
	HPA001164	U-251 MG	Nucleus	Spatial
	HPA001164	U-251 MG	Nucleoli	Spatial
	HPA000451	A-431	Nucleus	Spatial
	HPA000451	A-431	Nucleoli	Spatial
	HPA000451	U-2 OS	Nucleus	Spatial
	HPA000451	U-2 OS	Nucleoli
	HPA000451	U-251 MG	Nucleus	Spatial
	HPA000451	U-251 MG	Nucleoli	Spatial
	CAB000058	A-431	Nucleus	Spatial
	CAB000058	A-431	Nucleoli	Spatial
	CAB000058	U-2 OS	Nucleus	Spatial
	CAB000058	U-2 OS	Nucleoli	Spatial
	CAB000058	U-251 MG	Nucleus	Spatial
	CAB000058	U-251 MG	Nucleoli	Spatial

GENE INFORMATION
Gene name	MKI67 (HGNC Symbol)
Synonyms	MIB-, PPP1R105
Description	Marker of proliferation Ki-67 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	128096659 - 128126385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148773 (version 83.38)
Entrez gene	4288
UniProt	P46013 (UniProt - Evidence at protein level)
neXtProt	NX_P46013
Antibodypedia	MKI67 antibodies

PROTEIN BROWSER

MKI67-001	MKI67-002	MKI67-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKI67-001 ENSP00000357643 ENST00000368654	P46013 [Direct mapping] Antigen KI-67 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000793 [condensed chromosome] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006259 [DNA metabolic process] GO:0007126 [meiotic nuclear division] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0030212 [hyaluronan metabolic process] GO:0031100 [organ regeneration] GO:0034605 [cellular response to heat] GO:0044822 [poly(A) RNA binding] GO:0072574 [hepatocyte proliferation] GO:1990705 [cholangiocyte proliferation] Show all	3256 aa 358.7 kDa	No	0
MKI67-002 ENSP00000357642 ENST00000368653	P46013 [Direct mapping] Antigen KI-67 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	2896 aa 319.4 kDa	No	0
MKI67-201 ENSP00000479215 ENST00000617118	A0A087WV66 [Direct mapping] Antigen KI-67 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	3255 aa 358.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.