Expression of MKI67 in cancer - Summary

GENERAL INFORMATION
Gene name	MKI67
Gene description	Marker of proliferation Ki-67
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression most abundant in germinal center cells and in a subset of cells in several tissues including squamous epithelia, cells in seminiferous ducts and the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 4 antibodies. HPA000451 , HPA001164 , CAB000058 , CAB068198
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000451	HPA001164	CAB000058	CAB068198

GENE INFORMATION
Gene name	MKI67 (HGNC Symbol)
Synonyms	MIB-, PPP1R105
Description	Marker of proliferation Ki-67 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	128096659 - 128126385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148773 (version 83.38)
Entrez gene	4288
UniProt	P46013 (UniProt - Evidence at protein level)
neXtProt	NX_P46013
Antibodypedia	MKI67 antibodies

PROTEIN BROWSER

MKI67-001	MKI67-002	MKI67-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKI67-001 ENSP00000357643 ENST00000368654	P46013 [Direct mapping] Antigen KI-67 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000793 [condensed chromosome] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006259 [DNA metabolic process] GO:0007126 [meiotic nuclear division] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0030212 [hyaluronan metabolic process] GO:0031100 [organ regeneration] GO:0034605 [cellular response to heat] GO:0044822 [poly(A) RNA binding] GO:0072574 [hepatocyte proliferation] GO:1990705 [cholangiocyte proliferation] Show all	3256 aa 358.7 kDa	No	0
MKI67-002 ENSP00000357642 ENST00000368653	P46013 [Direct mapping] Antigen KI-67 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	2896 aa 319.4 kDa	No	0
MKI67-201 ENSP00000479215 ENST00000617118	A0A087WV66 [Direct mapping] Antigen KI-67 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	3255 aa 358.6 kDa	No	0