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CYP17A1

GENERAL INFORMATION

Gene name

 CYP17A1

Gene description

 Cytochrome P450, family 17, subfamily A, polypeptide 1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (HMC-1, SCLC-21H)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High expression in Leydig cells and adrenal cotical cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA048533
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048533

GENE INFORMATION

Gene name

 CYP17A1 (HGNC Symbol)

Synonyms

 CPT7, CYP17, P450C17, S17AH

Description

 Cytochrome P450, family 17, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102830531 - 102837533

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148795 (version 83.38)

Entrez gene

 1586

UniProt

 P05093 (UniProt - Evidence at protein level)

neXtProt

 NX_P05093

Antibodypedia

 CYP17A1 antibodies

PROTEIN BROWSER
CYP17A1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP17A1-001
ENSP00000358903
ENST00000369887
P05093 [Direct mapping]
Steroid 17-alpha-hydroxylase/17,20 lyase
Q1HB44 [Target identity:100%; Query identity:100%]
Cytochrome P450, family 17, subfamily A, polypeptide 1; cDNA FLJ78498, highly similar to Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1), mRNA
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Lyases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0004508 [steroid 17-alpha-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006082 [organic acid metabolic process]
GO:0006694 [steroid biosynthetic process]
GO:0006702 [androgen biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007548 [sex differentiation]
GO:0008202 [steroid metabolic process]
GO:0008584 [male gonad development]
GO:0009635 [response to herbicide]
GO:0009636 [response to toxic substance]
GO:0010033 [response to organic substance]
GO:0010034 [response to acetate]
GO:0010212 [response to ionizing radiation]
GO:0014070 [response to organic cyclic compound]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0017085 [response to insecticide]
GO:0018879 [biphenyl metabolic process]
GO:0018894 [dibenzo-p-dioxin metabolic process]
GO:0018958 [phenol-containing compound metabolic process]
GO:0018963 [phthalate metabolic process]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0021766 [hippocampus development]
GO:0030325 [adrenal gland development]
GO:0030424 [axon]
GO:0030728 [ovulation]
GO:0031667 [response to nutrient levels]
GO:0032526 [response to retinoic acid]
GO:0033327 [Leydig cell differentiation]
GO:0034097 [response to cytokine]
GO:0034698 [response to gonadotropin]
GO:0042446 [hormone biosynthetic process]
GO:0042448 [progesterone metabolic process]
GO:0042493 [response to drug]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0047442 [17-alpha-hydroxyprogesterone aldolase activity]
GO:0048545 [response to steroid hormone]
GO:0051591 [response to cAMP]
GO:0051597 [response to methylmercury]
GO:0055114 [oxidation-reduction process]
GO:0060992 [response to fungicide]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071236 [cellular response to antibiotic]
GO:0071371 [cellular response to gonadotropin stimulus]
GO:0090031 [positive regulation of steroid hormone biosynthetic process]
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 508 aa
57.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.