Expression of APIP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APIP
Gene description	APAF1 interacting protein
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression at variable levels in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA021188 , HPA024131
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA021188	HPA024131

GENE INFORMATION
Gene name	APIP (HGNC Symbol)
Synonyms	APIP2, CGI-29, Mmrp19
Description	APAF1 interacting protein (HGNC Symbol)
Entrez gene summary	APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
Chromosome	11
Cytoband	p13
Chromosome location (bp)	34853094 - 34916499
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149089 (version 83.38)
Entrez gene	51074
UniProt	Q96GX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GX9
Antibodypedia	APIP antibodies

PROTEIN BROWSER

APIP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APIP-001 ENSP00000379133 ENST00000395787	Q96GX9 [Direct mapping] Methylthioribulose-1-phosphate dehydratase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006595 [polyamine metabolic process] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0019284 [L-methionine biosynthetic process from S-adenosylmethionine] GO:0019509 [L-methionine biosynthetic process from methylthioadenosine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0046570 [methylthioribulose 1-phosphate dehydratase activity] GO:0046872 [metal ion binding] GO:0070372 [regulation of ERK1 and ERK2 cascade] Show all	242 aa 27.1 kDa	No	0