Expression of SLC43A1 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC43A1
Gene description	Solute carrier family 43 (amino acid system L transporter), member 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues. High expression in exocrine glandular cells in pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA018813 , HPA018826
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA018813	HPA018826

GENE INFORMATION
Gene name	SLC43A1 (HGNC Symbol)
Synonyms	PB39, POV1, R00504
Description	Solute carrier family 43 (amino acid system L transporter), member 1 (HGNC Symbol)
Entrez gene summary	SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	57484534 - 57515786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149150 (version 83.38)
Entrez gene	8501
UniProt	O75387 (UniProt - Evidence at protein level)
neXtProt	NX_O75387
Antibodypedia	SLC43A1 antibodies

PROTEIN BROWSER

SLC43A1-001	SLC43A1-002	SLC43A1-003	SLC43A1-005	SLC43A1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC43A1-001 ENSP00000278426 ENST00000278426	O75387 [Direct mapping] Large neutral amino acids transporter small subunit 3 A0A024R4Y3 [Target identity:100%; Query identity:100%] Solute carrier family 43, member 1, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0015807 [L-amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	559 aa 61.5 kDa	No	>9
SLC43A1-002 ENSP00000435673 ENST00000528450	O75387 [Direct mapping] Large neutral amino acids transporter small subunit 3 A0A024R4Y3 [Target identity:100%; Query identity:100%] Solute carrier family 43, member 1, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	559 aa 61.5 kDa	No	>9
SLC43A1-003 ENSP00000435486 ENST00000533263	E9PJT8 [Direct mapping] Large neutral amino acids transporter small subunit 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	110 aa 12.4 kDa	No	2
SLC43A1-005 ENSP00000435647 ENST00000533066	E9PJ68 [Direct mapping] Large neutral amino acids transporter small subunit 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	259 aa 28.4 kDa	No	6
SLC43A1-010 ENSP00000435803 ENST00000525764	H0YEH0 [Direct mapping] Large neutral amino acids transporter small subunit 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	186 aa 20.4 kDa	No	3