Fields »
ABOUT
HELP
BLOG
ARFGAP2

GENERAL INFORMATION

Gene name

 ARFGAP2

Gene description

 ADP-ribosylation factor GTPase activating protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA016649 , HPA018152
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016649
HPA018152

GENE INFORMATION

Gene name

 ARFGAP2 (HGNC Symbol)

Synonyms

 FLJ14576, IRZ, Zfp289, ZNF289

Description

 ADP-ribosylation factor GTPase activating protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47164299 - 47177125

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149182 (version 83.38)

Entrez gene

 84364

UniProt

 Q8N6H7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N6H7

Antibodypedia

 ARFGAP2 antibodies

PROTEIN BROWSER
«
ARFGAP2-001
ARFGAP2-002
ARFGAP2-015
ARFGAP2-017
ARFGAP2-021
ARFGAP2-023
ARFGAP2-026
ARFGAP2-027
ARFGAP2-201
ARFGAP2-202
ARFGAP2-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFGAP2-001
ENSP00000434442
ENST00000524782
Q8N6H7 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 521 aa
56.7 kDa 		No 0
ARFGAP2-002
ENSP00000431684
ENST00000528444
E9PK28 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 239 aa
26.1 kDa 		No 0
ARFGAP2-015
ENSP00000434809
ENST00000525314
E9PN48 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 252 aa
27.1 kDa 		No 0
ARFGAP2-017
ENSP00000434433
ENST00000527927
E9PQP3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0043547 [positive regulation of GTPase activity]
Show all
 274 aa
30.6 kDa 		No 0
ARFGAP2-021
ENSP00000435488
ENST00000530596
E9PJT7 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 173 aa
19.4 kDa 		No 0
ARFGAP2-023
ENSP00000431939
ENST00000525398
E9PIY6 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 327 aa
36.1 kDa 		No 0
ARFGAP2-026
ENSP00000437305
ENST00000526342
E9PMU9 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 156 aa
17.4 kDa 		No 0
ARFGAP2-027
ENSP00000434022
ENST00000527776
H0YDN9 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 237 aa
25.7 kDa 		No 0
ARFGAP2-201
ENSP00000400226
ENST00000426335
G5E9L0 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0043547 [positive regulation of GTPase activity]
Show all
 493 aa
53.5 kDa 		No 0
ARFGAP2-202
ENSP00000486339
ENST00000627920
A0A0D9SF70 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2; Zinc finger protein 289, ID1 regulated, isoform CRA_d
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 385 aa
42.2 kDa 		No 0
ARFGAP2-203
ENSP00000486229
ENST00000629231
E9PM18 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 70 aa
7.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.