Expression of ADAM33 in cancer - Summary - The Human Protein Atlas

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ADAM33

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM33
Gene description	ADAM metallopeptidase domain 33
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ, BJ hTERT+, U-2197)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA067152
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067152

GENE INFORMATION
Gene name	ADAM33 (HGNC Symbol)
Synonyms	C20orf153, dJ964F7.1, DKFZp434K0521
Description	ADAM metallopeptidase domain 33 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3667965 - 3682246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149451 (version 83.38)
Entrez gene	80332
UniProt	Q9BZ11 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZ11
Antibodypedia	ADAM33 antibodies

PROTEIN BROWSER

ADAM33-001	ADAM33-005	ADAM33-201	ADAM33-202	ADAM33-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM33-001 ENSP00000348912 ENST00000356518	Q9BZ11 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 33 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	813 aa 87.7 kDa	Yes	1
ADAM33-005 ENSP00000369190 ENST00000379861	A2A2L3 [Direct mapping] ADAM metallopeptidase domain 33, isoform CRA_g; Disintegrin and metalloproteinase domain-containing protein 33 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	812 aa 87.7 kDa	Yes	1
ADAM33-201 ENSP00000322550 ENST00000350009	Q9BZ11 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 33 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	787 aa 84.7 kDa	Yes	1
ADAM33-202 ENSP00000483343 ENST00000617732	Q08AM3 [Direct mapping] ADAM33 protein; Disintegrin and metalloproteinase domain-containing protein 33 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	138 aa 15.3 kDa	Yes	0
ADAM33-203 ENSP00000484600 ENST00000619289	Q08AM2 [Direct mapping] ADAM33 protein; Disintegrin and metalloproteinase domain-containing protein 33 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	692 aa 75.3 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.