Cell atlas - TMC2 - The Human Protein Atlas

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TMC2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TMC2
Gene description	Transmembrane channel-like 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at transcript level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TMC2 (HGNC Symbol)
Synonyms	C20orf145, dJ686C3.3
Description	Transmembrane channel-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2536607 - 2641784
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000149488 (version 83.38)
Entrez gene	117532
UniProt	Q8TDI7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDI7
Antibodypedia	TMC2 antibodies

PROTEIN BROWSER

TMC2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC2-001 ENSP00000351732 ENST00000358864	Q8TDI7 [Direct mapping] Transmembrane channel-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0016021 [integral component of membrane] GO:0032426 [stereocilium bundle tip] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0060005 [vestibular reflex] GO:0070588 [calcium ion transmembrane transport] Show all	906 aa 102.6 kDa	No	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.