Expression of TMC2 in cancer - Summary - The Human Protein Atlas

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TMC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMC2
Gene description	Transmembrane channel-like 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046350
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046350

GENE INFORMATION
Gene name	TMC2 (HGNC Symbol)
Synonyms	C20orf145, dJ686C3.3
Description	Transmembrane channel-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2536607 - 2641784
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000149488 (version 83.38)
Entrez gene	117532
UniProt	Q8TDI7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDI7
Antibodypedia	TMC2 antibodies

PROTEIN BROWSER

TMC2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC2-001 ENSP00000351732 ENST00000358864	Q8TDI7 [Direct mapping] Transmembrane channel-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0016021 [integral component of membrane] GO:0032426 [stereocilium bundle tip] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0060005 [vestibular reflex] GO:0070588 [calcium ion transmembrane transport] Show all	906 aa 102.6 kDa	No	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.