Cell atlas - ROM1 - The Human Protein Atlas

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ROM1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ROM1
Gene description	Retinal outer segment membrane protein 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028910
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028910	A-431	Plasma membrane
	HPA028910	A-431	Cytosol
	HPA028910	U-2 OS	Plasma membrane
	HPA028910	U-2 OS	Cytosol
	HPA028910	U-251 MG	Nucleoplasm	Spatial
			Plasma membrane
			Cytosol	Spatial

GENE INFORMATION
Gene name	ROM1 (HGNC Symbol)
Synonyms	ROM, TSPAN23
Description	Retinal outer segment membrane protein 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62611722 - 62615120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149489 (version 83.38)
Entrez gene	6094
UniProt	Q03395 (UniProt - Evidence at protein level)
neXtProt	NX_Q03395
Antibodypedia	ROM1 antibodies

PROTEIN BROWSER

ROM1-001	ROM1-002	ROM1-003	ROM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROM1-001 ENSP00000278833 ENST00000278833	Q03395 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007601 [visual perception] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0042622 [photoreceptor outer segment membrane] GO:0060042 [retina morphogenesis in camera-type eye] GO:0060219 [camera-type eye photoreceptor cell differentiation] GO:0061298 [retina vasculature development in camera-type eye] Show all	351 aa 37.2 kDa	No	4
ROM1-002 ENSP00000433566 ENST00000525801	E9PKF5 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted intracellular proteins Show all		58 aa 6.1 kDa	No	0
ROM1-003 ENSP00000432151 ENST00000534093	E9PS24 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted intracellular proteins Show all		105 aa 11.6 kDa	No	0
ROM1-004 ENSP00000432983 ENST00000525947	E9PMR7 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted intracellular proteins Show all		101 aa 11.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.