Expression of ROM1 in cancer - Summary - The Human Protein Atlas

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ROM1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ROM1
Gene description	Retinal outer segment membrane protein 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in photoreceptor cells.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation.
Reliability score	Supported based on 1 antibody. HPA028910
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028910

GENE INFORMATION
Gene name	ROM1 (HGNC Symbol)
Synonyms	ROM, TSPAN23
Description	Retinal outer segment membrane protein 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62611722 - 62615120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149489 (version 83.38)
Entrez gene	6094
UniProt	Q03395 (UniProt - Evidence at protein level)
neXtProt	NX_Q03395
Antibodypedia	ROM1 antibodies

PROTEIN BROWSER

ROM1-001	ROM1-002	ROM1-003	ROM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROM1-001 ENSP00000278833 ENST00000278833	Q03395 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007601 [visual perception] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0042622 [photoreceptor outer segment membrane] GO:0060042 [retina morphogenesis in camera-type eye] GO:0060219 [camera-type eye photoreceptor cell differentiation] GO:0061298 [retina vasculature development in camera-type eye] Show all	351 aa 37.2 kDa	No	4
ROM1-002 ENSP00000433566 ENST00000525801	E9PKF5 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted intracellular proteins Show all		58 aa 6.1 kDa	No	0
ROM1-003 ENSP00000432151 ENST00000534093	E9PS24 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted intracellular proteins Show all		105 aa 11.6 kDa	No	0
ROM1-004 ENSP00000432983 ENST00000525947	E9PMR7 [Direct mapping] Rod outer segment membrane protein 1 Show all	Predicted intracellular proteins Show all		101 aa 11.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.