Fields »
ABOUT
HELP
BLOG
INCENP

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 INCENP

Gene description

 Inner centromere protein antigens 135/155kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus, nuclear bodies & midbody

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nuclear bodies (supported), Midbody (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA070550
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus, nuclear bodies & midbody

Main location

 Nucleus (supported), Nuclear bodies (supported), Midbody (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA070550 HaCaT Nucleus Intensity
Nuclear bodies Intensity
HPA070550 MCF7 Nucleus Intensity
Midbody Intensity Intensity
HPA070550 U-2 OS Nuclear bodies Intensity
Cytosol

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Midbody, Nuclear bodies, Nucleus

GENE INFORMATION

Gene name

 INCENP (HGNC Symbol)

Synonyms

 FLJ31633

Description

 Inner centromere protein antigens 135/155kDa (HGNC Symbol)

Entrez gene summary

 In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62123973 - 62153163

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149503 (version 83.38)

Entrez gene

 3619

UniProt

 Q9NQS7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQS7

Antibodypedia

 INCENP antibodies

PROTEIN BROWSER
INCENP-001
INCENP-002
INCENP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INCENP-001
ENSP00000378295
ENST00000394818
Q9NQS7 [Direct mapping]
Inner centromere protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000795 [synaptonemal complex]
GO:0000800 [lateral element]
GO:0000801 [central element]
GO:0000910 [cytokinesis]
GO:0005515 [protein binding]
GO:0005721 [pericentric heterochromatin]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010369 [chromocenter]
GO:0030496 [midbody]
GO:0043234 [protein complex]
Show all
 918 aa
105.4 kDa 		No 0
INCENP-002
ENSP00000278849
ENST00000278849
Q9NQS7 [Direct mapping]
Inner centromere protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0005515 [protein binding]
GO:0005721 [pericentric heterochromatin]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043234 [protein complex]
Show all
 914 aa
105 kDa 		No 0
INCENP-004
ENSP00000433100
ENST00000533896
E9PM67 [Direct mapping]
Inner centromere protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 167 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.