Expression of EI24 in cancer - Summary - The Human Protein Atlas

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EI24

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EI24
Gene description	Etoposide induced 2.4
Protein class	Cancer-related genes Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, including parathyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA047165 , HPA051029
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047165	HPA051029

GENE INFORMATION
Gene name	EI24 (HGNC Symbol)
Synonyms	EPG4, PIG8, TP53I8
Description	Etoposide induced 2.4 (HGNC Symbol)
Entrez gene summary	This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125569216 - 125584687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149547 (version 83.38)
Entrez gene	9538
UniProt	O14681 (UniProt - Evidence at protein level)
neXtProt	NX_O14681
Antibodypedia	EI24 antibodies

PROTEIN BROWSER

EI24-001	EI24-002	EI24-003	EI24-004	EI24-006	EI24-007	EI24-008	EI24-009	EI24-011	EI24-013	EI24-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EI24-001 ENSP00000484510 ENST00000620753	O14681 [Direct mapping] Etoposide-induced protein 2.4 homolog A0A024R3I8 [Target identity:100%; Query identity:100%] Etoposide induced 2.4 mRNA, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] GO:0031965 [nuclear membrane] Show all	340 aa 39 kDa	No	6
EI24-002 ENSP00000278903 ENST00000278903	O14681 [Direct mapping] Etoposide-induced protein 2.4 homolog A0A024R3I8 [Target identity:100%; Query identity:100%] Etoposide induced 2.4 mRNA, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] GO:0031965 [nuclear membrane] Show all	340 aa 39 kDa	No	6
EI24-003 ENSP00000477849 ENST00000615917	B7ZB74 [Direct mapping] Etoposide-induced protein 2.4 homolog; cDNA, FLJ79438, highly similar to Etoposide-induced protein 2.4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	167 aa 19.1 kDa	No	4
EI24-004 ENSP00000480094 ENST00000618552	B7ZB74 [Direct mapping] Etoposide-induced protein 2.4 homolog; cDNA, FLJ79438, highly similar to Etoposide-induced protein 2.4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	167 aa 19.1 kDa	No	4
EI24-006 ENSP00000479943 ENST00000534546	O14681 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] GO:0031965 [nuclear membrane] Show all	326 aa 37.5 kDa	No	6
EI24-007 ENSP00000436130 ENST00000529812	E9PQN7 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		14 aa 1.6 kDa	No	0
EI24-008 ENSP00000433376 ENST00000527131	E9PL33 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.6 kDa	No	1
EI24-009 ENSP00000435034 ENST00000527842	E9PM05 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	187 aa 21.6 kDa	No	3
EI24-011 ENSP00000435923 ENST00000524723	E9PS58 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	217 aa 25.1 kDa	No	2
EI24-013 ENSP00000435225 ENST00000527520	E9PLB8 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.8 kDa	No	1
EI24-018 ENSP00000431633 ENST00000527235	E9PK61 [Direct mapping] Etoposide-induced protein 2.4 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	262 aa 30.1 kDa	No	4

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The Human Protein Atlas

The Human Protein Atlas project is funded
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