Expression of MPZL2 in cancer - Summary - The Human Protein Atlas

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MPZL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPZL2
Gene description	Myelin protein zero-like 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21, HaCaT, RT4, TIME)
HPA (normal tissue):	Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA060740
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and thyroid cancer (favourable).
Pancreatic cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060740

GENE INFORMATION
Gene name	MPZL2 (HGNC Symbol)
Synonyms	EVA, EVA1
Description	Myelin protein zero-like 2 (HGNC Symbol)
Entrez gene summary	Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118253403 - 118264536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149573 (version 83.38)
Entrez gene	10205
UniProt	O60487 (UniProt - Evidence at protein level)
neXtProt	NX_O60487
Antibodypedia	MPZL2 antibodies

PROTEIN BROWSER

MPZL2-001	MPZL2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPZL2-001 ENSP00000278937 ENST00000278937	O60487 [Direct mapping] Myelin protein zero-like protein 2 A0A024R3K1 [Target identity:100%; Query identity:100%] Epithelial V-like antigen 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0033077 [T cell differentiation in thymus] Show all	215 aa 24.5 kDa	Yes	1
MPZL2-002 ENSP00000408362 ENST00000438295	O60487 [Direct mapping] Myelin protein zero-like protein 2 A0A024R3K1 [Target identity:100%; Query identity:100%] Epithelial V-like antigen 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] Show all	215 aa 24.5 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.