Cell atlas - TBX6 - The Human Protein Atlas

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TBX6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TBX6
Gene description	T-box 6
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (RT4, U-266/70)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TBX6
Synonyms
Description	T-box 6 (HGNC Symbol)
Entrez gene summary	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30085793 - 30091887
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149922 (version 83.38)
Entrez gene	6911
UniProt	O95947 (UniProt - Evidence at protein level)
neXtProt	NX_O95947
Antibodypedia	TBX6 antibodies

PROTEIN BROWSER

TBX6-001	TBX6-002	TBX6-201	TBX6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBX6-001 ENSP00000378650 ENST00000395224	O95947 [Direct mapping] T-box transcription factor TBX6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0001707 [mesoderm formation] GO:0001708 [cell fate specification] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0009653 [anatomical structure morphogenesis] GO:0010977 [negative regulation of neuron projection development] GO:0014043 [negative regulation of neuron maturation] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0032525 [somite rostral/caudal axis specification] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	436 aa 47 kDa	No	0
TBX6-002 ENSP00000461223 ENST00000553607	O95947 [Direct mapping] T-box transcription factor TBX6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0009653 [anatomical structure morphogenesis] Show all	295 aa 33.2 kDa	No	0
TBX6-201 ENSP00000279386 ENST00000279386	O95947 [Direct mapping] T-box transcription factor TBX6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0009653 [anatomical structure morphogenesis] Show all	436 aa 47 kDa	No	0
TBX6-202 ENSP00000485762 ENST00000627355	A0A0D9SEK4 [Direct mapping] T-box transcription factor TBX6 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	436 aa 46.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.