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TBX6

GENERAL INFORMATION

Gene name

 TBX6

Gene description

 T-box 6

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RT4, U-266/70)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TBX6

Synonyms

Description

 T-box 6 (HGNC Symbol)

Entrez gene summary

 This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 30085793 - 30091887

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149922 (version 83.38)

Entrez gene

 6911

UniProt

 O95947 (UniProt - Evidence at protein level)

neXtProt

 NX_O95947

Antibodypedia

 TBX6 antibodies

PROTEIN BROWSER
TBX6-001
TBX6-002
TBX6-201
TBX6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBX6-001
ENSP00000378650
ENST00000395224
O95947 [Direct mapping]
T-box transcription factor TBX6
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001707 [mesoderm formation]
GO:0001708 [cell fate specification]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007498 [mesoderm development]
GO:0009653 [anatomical structure morphogenesis]
GO:0010977 [negative regulation of neuron projection development]
GO:0014043 [negative regulation of neuron maturation]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0032525 [somite rostral/caudal axis specification]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 436 aa
47 kDa 		No 0
TBX6-002
ENSP00000461223
ENST00000553607
O95947 [Direct mapping]
T-box transcription factor TBX6
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007498 [mesoderm development]
GO:0009653 [anatomical structure morphogenesis]
Show all
 295 aa
33.2 kDa 		No 0
TBX6-201
ENSP00000279386
ENST00000279386
O95947 [Direct mapping]
T-box transcription factor TBX6
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007498 [mesoderm development]
GO:0009653 [anatomical structure morphogenesis]
Show all
 436 aa
47 kDa 		No 0
TBX6-202
ENSP00000485762
ENST00000627355
A0A0D9SEK4 [Direct mapping]
T-box transcription factor TBX6
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 436 aa
46.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.