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ALDOA

GENERAL INFORMATION

Gene name

 ALDOA

Gene description

 Aldolase A, fructose-bisphosphate

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most cell types, including skeletal myocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004177 , CAB006252
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004177
CAB006252

GENE INFORMATION

Gene name

 ALDOA

Synonyms

Description

 Aldolase A, fructose-bisphosphate (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 30053090 - 30070457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149925 (version 83.38)

Entrez gene

 226

UniProt

 P04075 (UniProt - Evidence at protein level)

neXtProt

 NX_P04075

Antibodypedia

 ALDOA antibodies

PROTEIN BROWSER
«
ALDOA-001
ALDOA-002
ALDOA-003
ALDOA-004
ALDOA-005
ALDOA-006
ALDOA-007
ALDOA-008
ALDOA-009
ALDOA-010
ALDOA-011
ALDOA-017
ALDOA-019
ALDOA-020
ALDOA-022
ALDOA-028
ALDOA-030
ALDOA-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDOA-001
ENSP00000455917
ENST00000564546
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
V9HWN7 [Target identity:100%; Query identity:100%]
Fructose-bisphosphate aldolase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.4 kDa 		No 0
ALDOA-002
ENSP00000378669
ENST00000395248
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 418 aa
45.3 kDa 		Yes 0
ALDOA-003
ENSP00000457683
ENST00000568435
H3BUK5 [Direct mapping]
Fructose-bisphosphate aldolase A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 12 aa
1.4 kDa 		No 0
ALDOA-004
ENSP00000455724
ENST00000566897
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
V9HWN7 [Target identity:100%; Query identity:100%]
Fructose-bisphosphate aldolase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.4 kDa 		No 0
ALDOA-005
ENSP00000336927
ENST00000338110
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
V9HWN7 [Target identity:100%; Query identity:100%]
Fructose-bisphosphate aldolase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.4 kDa 		No 0
ALDOA-006
ENSP00000455800
ENST00000563060
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
V9HWN7 [Target identity:100%; Query identity:100%]
Fructose-bisphosphate aldolase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.4 kDa 		No 0
ALDOA-007
ENSP00000455700
ENST00000569545
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
V9HWN7 [Target identity:100%; Query identity:100%]
Fructose-bisphosphate aldolase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.4 kDa 		No 0
ALDOA-008
ENSP00000400452
ENST00000412304
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
V9HWN7 [Target identity:100%; Query identity:100%]
Fructose-bisphosphate aldolase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.4 kDa 		No 0
ALDOA-009
ENSP00000457468
ENST00000564595
P04075 [Direct mapping]
Fructose-bisphosphate aldolase A
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006754 [ATP biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0031093 [platelet alpha granule lumen]
GO:0031430 [M band]
GO:0031674 [I band]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046716 [muscle cell cellular homeostasis]
GO:0051289 [protein homotetramerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 418 aa
45.3 kDa 		Yes 0
ALDOA-010
ENSP00000455857
ENST00000569798
H3BQN4 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 361 aa
39.3 kDa 		No 0
ALDOA-011
ENSP00000378661
ENST00000395240
J3KPS3 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 368 aa
39.8 kDa 		No 0
ALDOA-017
ENSP00000456020
ENST00000562168
H3BR04 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 162 aa
17.8 kDa 		No 0
ALDOA-019
ENSP00000455455
ENST00000562679
H3BPS8 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 278 aa
30.4 kDa 		Yes 0
ALDOA-020
ENSP00000457643
ENST00000563987
H3BUH7 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 155 aa
16.9 kDa 		No 0
ALDOA-022
ENSP00000457514
ENST00000564688
H3BU78 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 204 aa
22.1 kDa 		No 0
ALDOA-028
ENSP00000456098
ENST00000565355
H3BR68 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 130 aa
13.7 kDa 		No 0
ALDOA-030
ENSP00000454499
ENST00000566846
H3BMQ8 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 140 aa
15.5 kDa 		No 0
ALDOA-201
ENSP00000485952
ENST00000627059
J3KPS3 [Direct mapping]
Fructose-bisphosphate aldolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004332 [fructose-bisphosphate aldolase activity]
GO:0006096 [glycolytic process]
Show all
 368 aa
39.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.