Expression of CNTN5 in cancer - Summary - The Human Protein Atlas

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CNTN5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNTN5
Gene description	Contactin 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex, placenta, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA039492 , HPA041223
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039492	HPA041223

GENE INFORMATION
Gene name	CNTN5 (HGNC Symbol)
Synonyms	hNB-2, NB-2
Description	Contactin 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	11
Cytoband	q22.1
Chromosome location (bp)	99020953 - 100358885
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149972 (version 83.38)
Entrez gene	53942
UniProt	O94779 (UniProt - Evidence at protein level)
neXtProt	NX_O94779
Antibodypedia	CNTN5 antibodies

PROTEIN BROWSER

CNTN5-001	CNTN5-003	CNTN5-004	CNTN5-006	CNTN5-201	CNTN5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTN5-001 ENSP00000435637 ENST00000524871	O94779 [Direct mapping] Contactin-5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007605 [sensory perception of sound] GO:0031225 [anchored component of membrane] Show all	1100 aa 120.7 kDa	Yes	0
CNTN5-003 ENSP00000433575 ENST00000527185	O94779 [Direct mapping] Contactin-5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0031225 [anchored component of membrane] Show all	911 aa 100.3 kDa	Yes	0
CNTN5-004 ENSP00000393229 ENST00000418526	O94779 [Direct mapping] Contactin-5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0031225 [anchored component of membrane] Show all	1026 aa 112.7 kDa	Yes	0
CNTN5-006 ENSP00000436185 ENST00000528682	O94779 [Direct mapping] Contactin-5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0031225 [anchored component of membrane] Show all	1100 aa 120.7 kDa	Yes	0
CNTN5-201 ENSP00000279463 ENST00000279463	A0A0A0MQX5 [Direct mapping] Contactin-5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	1084 aa 118.9 kDa	No	0
CNTN5-202 ENSP00000478120 ENST00000619298	A0A087WTT8 [Direct mapping] Contactin-5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	1022 aa 112.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.