We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
AT rich interactive domain 5B (MRF1-like) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Q14865 [Direct mapping] AT-rich interactive domain-containing protein 5B
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001822 [kidney development] GO:0001889 [liver development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006807 [nitrogen compound metabolic process] GO:0008584 [male gonad development] GO:0008585 [female gonad development] GO:0009791 [post-embryonic development] GO:0010761 [fibroblast migration] GO:0030325 [adrenal gland development] GO:0035264 [multicellular organism growth] GO:0044212 [transcription regulatory region DNA binding] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048468 [cell development] GO:0048644 [muscle organ morphogenesis] GO:0048705 [skeletal system morphogenesis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060021 [palate development] GO:0060325 [face morphogenesis] GO:0060612 [adipose tissue development] GO:0060613 [fat pad development]
Q14865 [Direct mapping] AT-rich interactive domain-containing protein 5B
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001889 [liver development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060612 [adipose tissue development]
