Expression of N6AMT2 in cancer - Summary - The Human Protein Atlas

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N6AMT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	N6AMT2
Gene description	N-6 adenine-specific DNA methyltransferase 2 (putative)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA040417 , HPA042543
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040417	HPA042543

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most of the cancer tissues displayed weak to moderate cytoplasmic positivity. Additional membranous staining was observed in several cases of cervical, colorectal, endometrial, ovarian and pancreatic cancers. Many carcinoids, lymphomas, prostate and liver cancers were negative.

GENE INFORMATION
Gene name	N6AMT2
Synonyms
Description	N-6 adenine-specific DNA methyltransferase 2 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	20728731 - 20773958
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150456 (version 83.38)
Entrez gene	221143
UniProt	Q8WVE0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVE0
Antibodypedia	N6AMT2 antibodies

PROTEIN BROWSER

N6AMT2-001	N6AMT2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
N6AMT2-001 ENSP00000372202 ENST00000382754	Q8WVE0 [Direct mapping] Protein-lysine N-methyltransferase N6AMT2 A0A024RDN3 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0070062 [extracellular exosome] Show all	214 aa 24.5 kDa	No	0
N6AMT2-002 ENSP00000372206 ENST00000382758	Q8WVE0 [Direct mapping] Protein-lysine N-methyltransferase N6AMT2 A0A024RDN3 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0070062 [extracellular exosome] Show all	214 aa 24.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.