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DLAT

GENERAL INFORMATION

Gene name

 DLAT

Gene description

 Dihydrolipoamide S-acetyltransferase

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040786 , CAB003782
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040786
CAB003782

GENE INFORMATION

Gene name

 DLAT (HGNC Symbol)

Synonyms

 DLTA, PDC-E2

Description

 Dihydrolipoamide S-acetyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]

Chromosome

 11

Cytoband

 q23.1

Chromosome location (bp)

 112024814 - 112064390

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150768 (version 83.38)

Entrez gene

 1737

UniProt

 P10515 (UniProt - Evidence at protein level)

neXtProt

 NX_P10515

Antibodypedia

 DLAT antibodies

PROTEIN BROWSER
DLAT-001
DLAT-002
DLAT-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLAT-001
ENSP00000280346
ENST00000280346
P10515 [Direct mapping]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Q86YI5 [Target identity:100%; Query identity:100%]
Acetyltransferase component of pyruvate dehydrogenase complex
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004742 [dihydrolipoyllysine-residue acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005967 [mitochondrial pyruvate dehydrogenase complex]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0030431 [sleep]
GO:0034604 [pyruvate dehydrogenase (NAD+) activity]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
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 647 aa
69 kDa 		No 0
DLAT-002
ENSP00000376771
ENST00000393051
E9PEJ4 [Direct mapping]
Acetyltransferase component of pyruvate dehydrogenase complex
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004742 [dihydrolipoyllysine-residue acetyltransferase activity]
GO:0005759 [mitochondrial matrix]
GO:0006090 [pyruvate metabolic process]
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0045254 [pyruvate dehydrogenase complex]
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 542 aa
57.6 kDa 		No 0
DLAT-005
ENSP00000433432
ENST00000531306
H0YDD4 [Direct mapping]
Acetyltransferase component of pyruvate dehydrogenase complex
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004742 [dihydrolipoyllysine-residue acetyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006090 [pyruvate metabolic process]
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0045254 [pyruvate dehydrogenase complex]
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 479 aa
51.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.