Cell atlas - SLC7A11 - The Human Protein Atlas

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SLC7A11

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SLC7A11
Gene description	Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Protein class	FDA approved drug targets Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064215
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064215	A549	Vesicles
	HPA064215	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SLC7A11 (HGNC Symbol)
Synonyms	xCT
Description	Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Chromosome	4
Cytoband	q28.3
Chromosome location (bp)	138164097 - 138242349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151012 (version 83.38)
Entrez gene	23657
UniProt	Q9UPY5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPY5
Antibodypedia	SLC7A11 antibodies

PROTEIN BROWSER

SLC7A11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC7A11-001 ENSP00000280612 ENST00000280612	Q9UPY5 [Direct mapping] Cystine/glutamate transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005515 [protein binding] GO:0005791 [rough endoplasmic reticulum] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0006979 [response to oxidative stress] GO:0007420 [brain development] GO:0007596 [blood coagulation] GO:0009636 [response to toxic substance] GO:0009986 [cell surface] GO:0015171 [amino acid transmembrane transporter activity] GO:0015327 [cystine:glutamate antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035094 [response to nicotine] GO:0043231 [intracellular membrane-bounded organelle] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:0070306 [lens fiber cell differentiation] GO:0070527 [platelet aggregation] GO:0089711 [L-glutamate transmembrane transport] Show all	501 aa 55.4 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.