Tissue expression of SLC7A11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC7A11
Gene description	Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Protein class	FDA approved drug targets Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (caudate)
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION
Gene name	SLC7A11 (HGNC Symbol)
Synonyms	xCT
Description	Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Chromosome	4
Cytoband	q28.3
Chromosome location (bp)	138164097 - 138242349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151012 (version 83.38)
Entrez gene	23657
UniProt	Q9UPY5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPY5
Antibodypedia	SLC7A11 antibodies

PROTEIN BROWSER

SLC7A11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC7A11-001 ENSP00000280612 ENST00000280612	Q9UPY5 [Direct mapping] Cystine/glutamate transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005515 [protein binding] GO:0005791 [rough endoplasmic reticulum] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0006979 [response to oxidative stress] GO:0007420 [brain development] GO:0007596 [blood coagulation] GO:0009636 [response to toxic substance] GO:0009986 [cell surface] GO:0015171 [amino acid transmembrane transporter activity] GO:0015327 [cystine:glutamate antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035094 [response to nicotine] GO:0043231 [intracellular membrane-bounded organelle] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:0070306 [lens fiber cell differentiation] GO:0070527 [platelet aggregation] GO:0089711 [L-glutamate transmembrane transport] Show all	501 aa 55.4 kDa	No	>9