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NOCT

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GENERAL INFORMATION

Gene name

 NOCT

Gene description

 Nocturnin

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

Additional location

 In addition localized to the Nucleoplasm (approved), Cytosol (supported)

Mouse

 Localized to the Nuclear speckles in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA012287 , HPA053714
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

Main location

 Nuclear bodies (supported)

Additional location

 Nucleoplasm (approved), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA012287 A-431 Nucleoplasm
Cytosol
HPA012287 U-251 MG Nuclear bodies
Cytosol
HPA053714 A-431 Nuclear bodies
Cytosol
HPA053714 U-251 MG Nuclear bodies

MOUSE CELLS

Main location

 Nuclear speckles

Mouse gene

 ENSMUSG00000023087 (version 83)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA053714 NIH 3T3 Nuclear speckles

GENE INFORMATION

Gene name

 NOCT (HGNC Symbol)

Synonyms

 Ccr4c, CCR4L, CCRN4L, NOC

Description

 Nocturnin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q31.1

Chromosome location (bp)

 139015789 - 139045939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151014 (version 83.38)

Entrez gene

 25819

UniProt

 Q9UK39 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UK39

Antibodypedia

 NOCT antibodies

PROTEIN BROWSER
NOCT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOCT-001
ENSP00000280614
ENST00000280614
Q9UK39 [Direct mapping]
Nocturnin
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003729 [mRNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006397 [mRNA processing]
GO:0007623 [circadian rhythm]
GO:0009991 [response to extracellular stimulus]
GO:0010629 [negative regulation of gene expression]
GO:0032496 [response to lipopolysaccharide]
GO:0032922 [circadian regulation of gene expression]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0042752 [regulation of circadian rhythm]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045995 [regulation of embryonic development]
GO:0046872 [metal ion binding]
GO:0048255 [mRNA stabilization]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
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 431 aa
48.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.