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NGLY1

GENERAL INFORMATION

Gene name

 NGLY1

Gene description

 N-glycanase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036825
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036825

GENE INFORMATION

Gene name

 NGLY1 (HGNC Symbol)

Synonyms

 FLJ11005, PNG1

Description

 N-glycanase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

Chromosome

 3

Cytoband

 p24.2

Chromosome location (bp)

 25718944 - 25790039

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151092 (version 83.38)

Entrez gene

 55768

UniProt

 Q96IV0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96IV0

Antibodypedia

 NGLY1 antibodies

PROTEIN BROWSER
NGLY1-001
NGLY1-002
NGLY1-004
NGLY1-008
NGLY1-015
NGLY1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NGLY1-001
ENSP00000280700
ENST00000280700
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
 654 aa
74.4 kDa 		Yes 0
NGLY1-002
ENSP00000379886
ENST00000396649
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
 558 aa
63.8 kDa 		Yes 1
NGLY1-004
ENSP00000307980
ENST00000308710
A0A0C4DFP4 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
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 633 aa
72 kDa 		No 0
NGLY1-008
ENSP00000389888
ENST00000417874
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
 612 aa
70.2 kDa 		No 0
NGLY1-015
ENSP00000412946
ENST00000427041
C9JU75 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 114 aa
12.4 kDa 		No 0
NGLY1-201
ENSP00000387430
ENST00000428257
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
 636 aa
72.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.