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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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NGLY1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NGLY1

Gene description

N-glycanase 1

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA036825
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

NGLY1 (HGNC Symbol)

Synonyms

FLJ11005, PNG1

Description

N-glycanase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

Chromosome

3

Cytoband

p24.2

Chromosome location (bp)

25718944 - 25790039

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151092 (version 83.38)

Entrez gene

55768

UniProt

Q96IV0 (UniProt - Evidence at protein level)

neXtProt

NX_Q96IV0

Antibodypedia

NGLY1 antibodies

PROTEIN BROWSER

NGLY1-001
NGLY1-002
NGLY1-004
NGLY1-008
NGLY1-015
NGLY1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NGLY1-001
ENSP00000280700
ENST00000280700
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
654 aa
74.4 kDa
Yes 0
NGLY1-002
ENSP00000379886
ENST00000396649
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
558 aa
63.8 kDa
Yes 1
NGLY1-004
ENSP00000307980
ENST00000308710
A0A0C4DFP4 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
Show all
633 aa
72 kDa
No 0
NGLY1-008
ENSP00000389888
ENST00000417874
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
612 aa
70.2 kDa
No 0
NGLY1-015
ENSP00000412946
ENST00000427041
C9JU75 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
114 aa
12.4 kDa
No 0
NGLY1-201
ENSP00000387430
ENST00000428257
Q96IV0 [Direct mapping]
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000224 [peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
GO:0046872 [metal ion binding]
Show all
636 aa
72.3 kDa
Yes 0

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