Tissue expression of DLG5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DLG5
Gene description	Discs, large homolog 5 (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	DLG5 (HGNC Symbol)
Synonyms	KIAA0583, P-dlg
Description	Discs, large homolog 5 (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q22.3
Chromosome location (bp)	77790791 - 77926526
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151208 (version 83.38)
Entrez gene	9231
UniProt	Q8TDM6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDM6
Antibodypedia	DLG5 antibodies

PROTEIN BROWSER

DLG5-001	DLG5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLG5-001 ENSP00000361467 ENST00000372391	Q8TDM6 [Direct mapping] Disks large homolog 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0006461 [protein complex assembly] GO:0007165 [signal transduction] GO:0008013 [beta-catenin binding] GO:0008092 [cytoskeletal protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0016337 [single organismal cell-cell adhesion] GO:0030159 [receptor signaling complex scaffold activity] GO:0030859 [polarized epithelial cell differentiation] GO:0030901 [midbrain development] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0045176 [apical protein localization] GO:0045186 [zonula adherens assembly] GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0071896 [protein localization to adherens junction] GO:0072205 [metanephric collecting duct development] Show all	1919 aa 213.9 kDa	No	0
DLG5-005 ENSP00000394797 ENST00000424842	A0A0A0MSL1 [Direct mapping] Disks large homolog 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	880 aa 96.7 kDa	No	0